Terminal C(sp3)H alkylation of internal alkenes via Ni/H-catalyzed isomerization. Issue 23 (6th June 2018)

• Record Type: Journal Article
• Authors: Wang, Zhen-Yu; Wan, Jia-Hao; Wang, Gao-Yin; Wang, Rui; Jin, Ruo-Xing; Lan, Quan; Wang, Xi-Sheng
• Is Part Of: Tetrahedron letters. Volume 59:Issue 23(2018)
• Page Start: 2302
• Page End: 2305
• Publication Date: 2018-06-06
• Subjects: Nickel-catalyzed -- Isomerization -- Alkylation -- Terminal-selectivity -- Internal alkenes; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.05.008
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient nickel-catalyzed reductive relay cross-coupling of internal alkenes with alkyl/aryl halides has been developed. This method has demonstrated broad substrate scope, mild reaction conditions and excellent terminal-selectivity. The efficient strategy can be applied to the terminal-selective alkylation of isomeric mixtures of internal alkenes. Abstract: An efficient nickel-catalyzed reductive relay cross-coupling of internal alkenes with alkyl (or aryl) halides has been developed. This method has demonstrated broad substrate scope, mild reaction conditions and excellent terminal-selectivity. Moreover, this efficient strategy could be applied to the terminal-selective alkylation of isomeric mixtures of internal alkenes.