Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders. (March 2019)

• Record Type: Journal Article
• Authors: Carvalho, Carolina Muniz; Pan, Pedro M.; Ota, Vanessa K.; Spindola, Letícia M.; Xavier, Gabriela; Santoro, Marcos L.; Mazzotti, Diego R.; Pellegrino, Renata; Hakonarson, Hakon; Rohde, Luis Augusto; Miguel, Euripedes Constantino; Gadelha, Ary; Bressan, Rodrigo A.; Belangero, Sintia I.
• Is Part Of: Psychiatry research. Volume 273(2019)
• Page Start: 575
• Page End: 577
• Publication Date: 2019-03
• Subjects: G × E-interaction -- Child maltreatment -- Psychopathology; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2019.01.078
• Languages: English
• ISSNs: 0165-1781

Abstract

Highlights: SNPs were not associated to mental disorders or psychopathology in children. Candidate genes were not associated with increased risk to develop mental disorders. G × E was not associated to risk of develop mental disorder/psychopathology in children. Abstract: We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G × CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology). After Bonferroni multiple comparison correction, we did not find any statistically significant association of G × CM with either MD or psychopathology.