Mannose‐Binding Lectin–Deficient Donors Increase the Risk of Bacterial Infection and Bacterial Infection–Related Mortality After Liver Transplantation. Issue 1 (14th August 2017)

• Record Type: Journal Article
• Authors: Lombardo‐Quezada, J.; Sanclemente, G.; Colmenero, J.; Español‐Rego, M.; Arias, M. T.; Ruiz, P.; Mauro, E.; Sastre, L.; Crespo, G.; Rimola, A.; Moreno, A.; Lozano, F.; Navasa, M.
• Is Part Of: American journal of transplantation. Volume 18:Issue 1(2018)
• Page Start: 197
• Page End: 206
• Publication Date: 2017-08-14
• Subjects: clinical research/practice -- translational research/science -- liver transplantation/hepatology -- genetics -- infectious disease -- infection and infectious agents -- liver disease:immune/inflammatory -- genetics -- liver allograft function/dysfunction; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.14408
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Mannose‐binding lectin (MBL) is synthesized by the liver and binds to microbes. MBL2 gene polymorphisms produce intermediate/low/null or normal MBL serum levels (MBL‐deficient or MBL‐sufficient phenotypes, respectively). We aimed to evaluate the incidence and severity of infection, rejection, and survival within 1 year after liver transplantation (LT) according to donor and recipient MBL2 gene polymorphisms. A repeated‐event analysis for infection episodes (negative binomial regression, Andersen–Gill model) was performed in 240 LTs. Four hundred twenty‐eight infectious episodes (310 bacterial, 15 fungal, 65 cytomegalovirus [CMV]‐related, and 38 viral non–CMV‐related episodes) and 48 rejection episodes were recorded. The main bacterial infections were urinary (n = 82, 26%) and pneumonia (n = 69, 22%). LT recipients of MBL‐deficient livers had a higher risk of bacterial infection (incidence rate ratio [IRR] 1.48 [95% confidence interval 1.04–2.09], p = 0.028), pneumonia (IRR 2.4 [95% confidence interval 1.33–4.33], p = 0.013), and septic shock (IRR 5.62 [95% confidence interval 1.92–16.4], p = 0.002) compared with recipients of MBL‐deficient livers. The 1‐year bacterial infection–related mortality was higher in recipients of MBL‐deficient versus MBL‐sufficient livers (65.8% vs. 56.1%, respectively; p = 0.0097). The incidence of rejection, viral, or fungal infection was similar in both groups. Recipient MBL2 genotype did not significantly increase the risk of bacterial infection. LT recipients of MBL‐deficient livers have a higher risk of bacterial infection, pneumonia, septic shock, and 1‐year bacterial infection–related mortality after LT. Abstract : Liver transplant recipients of mannose‐binding lectin–deficient donors have a higher risk of bacterial infection and septic shock, and a higher one‐year bacterial infection–related mortality, which increase when both donor and recipient carry a deficient mannose‐binding lectin genotype and the recipient's MELD at transplant is >22.