Sarcoma‐Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies (Adv. Funct. Mater. 49/2020). (1st December 2020)

• Record Type: Journal Article
• Authors: Dong, Jiantong; Zhang, Ryan Y.; Sun, Na; Hu, Junhui; Smalley, Matthew D.; Zhou, Anqi; Hua, Yue; Rothermich, Winston; Chen, Mengxiang; Chen, Jiayuan; Ye, Jinglei; Teng, Pai‐Chi; Qi, Dongping; Toretsky, Jeffrey A.; Tomlinson, James S.; Li, Mengyuan; Weiss, Paul S.; Jonas, Steven J.; Federman, Noah; Wu, Lily; Zhao, Meiping; Tseng, Hsian‐Rong; Zhu, Yazhen
• Is Part Of: Advanced functional materials. Volume 30:Number 49(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-01
• Subjects: covalent chemistry -- extracellular vesicles -- microfluidics -- nanostructured substrates -- sarcoma; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202070322
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : In article number 2003237, Meiping Zhao, Hsian‐Rong Tseng, Yazhen Zhu, and co‐workers present a device for the purification of Ewing sarcoma‐derived extracellular vesicles (EVs) by coupling LINGO‐1 antibodies with the covalent chemistry‐mediated EV capture/release mechanism using a nanostructure‐embedded microchip. The purified EVs can be internalized by recipient cells to transfer the mRNA cargoes, highlighting the role of EVs as biological shuttles in intercellular communication.