Unraveling pancreatic islet biology by quantitative proteomics. (August 2011)

• Record Type: Journal Article
• Authors: Zhou, Jian-Ying; Dann, Geoffrey P; Liew, Chong Wee; Smith, Richard D; Kulkarni, Rohit N; Qian, Wei-Jun
• Is Part Of: Expert review of proteomics. Volume 8:Number 4(2011)
• Page Start: 495
• Page End: 504
• Publication Date: 2011-08
• Subjects: diabetes -- insulin resistance -- pancreatic ββcells -- pancreatic islets -- quantitative proteomics -- signaling pathway; Proteins -- Biotechnology -- Periodicals; Proteomics -- Periodicals; 572.6
• DOI: 10.1586/epr.11.39
• Languages: English
• ISSNs: 1478-9450

Abstract

The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathogenesis underlying both Type 1 and Type 2 diabetes. Over the past 5 years, emerging proteomic technologies have been applied to dissect the signaling pathways that regulate islet functions and gain an understanding of the mechanisms of islet dysfunction relevant to diabetes. Herein, we briefly review some of the recent quantitative proteomic studies involving pancreatic islets geared towards gaining a better understanding of islet biology relevant to metabolic diseases.