Coaxial electrospray of microparticles and nanoparticles for biomedical applications. (November 2012)

• Record Type: Journal Article
• Authors: Zhang, Leilei; Huang, Jiwei; Si, Ting; Xu, Ronald X
• Is Part Of: Expert review of medical devices. Volume 9:Number 6(2012)
• Page Start: 595
• Page End: 612
• Publication Date: 2012-11
• Subjects: coaxial electrospray -- drug delivery -- electrohydrodynamic atomization -- instability analysis -- microparticle -- multimodal imaging -- nanoparticle -- scaling law -- Taylor cone; Medical instruments and apparatus -- Periodicals; 610.28
• DOI: 10.1586/erd.12.58
• Languages: English
• ISSNs: 1743-4440

Abstract

Coaxial electrospray is an electrohydrodynamic process that produces multilayer microparticles and nanoparticles by introducing coaxial electrified jets. In comparison with other microencapsulation/nanoencapsulation processes, coaxial electrospray has several potential advantages such as high encapsulation efficiency, effective protection of bioactivity and uniform size distribution. However, process control in coaxial electrospray is challenged by the multiphysical nature of the process and the complex interplay of multiple design, process and material parameters. This paper reviews the previous works and the recent advances in design, modeling and control of a coaxial electrospray process. The review intends to provide general guidance for coaxial electrospray and stimulate further research and development interests in this promising microencapsulation/nanoencapsulation process.