Genome‐wide association study of periweaning failure‐to‐thrive syndrome (PFTS) in pigs. (25th June 2016)

• Record Type: Journal Article
• Authors: Zanella, R.; Morés, N.; Morés, M. A. Z.; Peixoto, J. O.; Zanella, E. L.; Ciacci‐Zanella, J. R.; Ibelli, A. M. G.; Gava, D.; Cantão, M. E.; Ledur, M. C.
• Is Part Of: Veterinary record. Volume 178:Number 26(2016)
• Page Start: 653
• Page End: 653
• Publication Date: 2016-06-25
• Subjects: Sus scrofa -- GWAS -- Depression -- SNP; Veterinary medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Veterinary medicine; Veterinary Medicine; Periodicals; Periodical; Electronic journals; 636.089
• DOI: 10.1136/vr.103546
• Languages: English
• ISSNs: 0042-4900

Abstract

Abstract : Porcine periweaning‐failure‐to‐thrive syndrome (PFTS) is a condition that affects newly weaned piglets. It is characterised by a progressive debilitation leading to death, in the absence of infectious, nutritional, management or environmental factors. In this study, we present the first report of PFTS in South America and the results of a genome‐wide association study to identify the genetic markers associated with the appearance of this condition in a crossbred swine population. Four chromosomal regions were associated with PFTS predisposition, one located on SSCX, one on SSC8, and the two other regions on SSC14. Regions on SSC8 and SSC14 harbour important functional candidate genes involved in human depression and might have an important role in PFTS. Our findings contribute to the increasing knowledge about this syndrome, which has been investigated since 2007, and to the identification of the aetiology of this disease.