Bromodomain‐containing protein 4 and its role in cardiovascular diseases. Issue 7 (20th December 2020)

• Record Type: Journal Article
• Authors: Li, Liang; Xie, Wei; Gui, Yu; Zheng, Xi‐Long
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 7(2021)
• Page Start: 4829
• Page End: 4840
• Publication Date: 2020-12-20
• Subjects: BRD4 -- cardiac hypertrophy -- cardiovascular diseases -- hypertension -- ischemic heart disease; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30225
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Bromodomain‐containing protein 4 (BRD4), a chromatin‐binding protein, is involved in the development of various tumors. Recent evidence suggests that BRD4 also plays a significant role in cardiovascular diseases, such as ischemic heart disease, hypertension, and cardiac hypertrophy. This review summarizes the roles of BRD4 as a potential regulator of various pathophysiological processes in cardiovascular diseases, implicating that BRD4 may be a new therapeutic target for cardiovascular diseases in the future. Abstract : This review summarizes the roles of BRD4 as a potential regulator of various pathophysiological processes in cardiovascular diseases, implicating that BRD4 may be a new therapeutic target for cardiovascular diseases in the future.