Cytokines in embryonic secretome as potential markers for embryo selection. (20th December 2020)

• Record Type: Journal Article
• Authors: Bahrami‐Asl, Zahra; Hajipour, Hamed; Rastgar Rezaei, Yeganeh; Novinbahador, Tannaz; Latifi, Zeinab; Nejabati, Hamid Reza; Farzadi, Laya; Fattahi, Amir; Nouri, Mohammad; Dominguez, Francisco
• Is Part Of: American journal of reproductive immunology. Volume 85:Number 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-20
• Subjects: culture media -- cytokines -- embryo -- implantation -- secretome; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.13385
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract: Despite performing certain morphological assessments for selecting the best embryo for transfer, the results have not been satisfactory. Given the global tendency for performing quick and noninvasive tests for embryo selection, great efforts have been made to discover the predictive biomarkers of embryo implantation potential. In recent years, many factors have been detected in embryo culture media as a major source of embryo secretions. Previous studies have evaluated cytokines, miRNAs, extracellular vesicles, and other factors such as leukemia inhibitory factor, colony‐stimulating factor, reactive oxygen species, soluble human leukocyte antigen G, amino acids, and apolipoproteins in these media. Given the key role of cytokines in embryo implantation, these factors can be considered promising molecules for predicting the implantation success of assisted reproductive technology (ART). The present study was conducted to review embryo‐secreted molecules as potential biomarkers for embryo selection in ART.