Spatiotemporal Magnetocaloric Microenvironment for Guiding the Fate of Biodegradable Polymer Implants. (8th February 2021)

• Record Type: Journal Article
• Authors: Hao, Lili; Li, Jiaxiang; Wang, Peng; Wang, Zongliang; Wu, Zhenxu; Wang, Yu; Jiao, Zixue; Guo, Min; Shi, Tongfei; Wang, Qigang; Ito, Yoshihiro; Wei, Yen; Zhang, Peibiao
• Is Part Of: Advanced functional materials. Volume 31:Number 15(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-02-08
• Subjects: biodegradable polymer implants -- bone tissue engineering -- magnetocaloric effect -- magneto‐controlled degradation -- spatiotemporal therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202009661
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: The degradation behavior of implants is significantly important for bone repair. However, it is still unprocurable to spatiotemporally regulate the degradation of the implants to match bone ingrowth. In this paper, a magneto‐controlled biodegradation model is established to explore the degradation behavior of magnetic scaffolds in a magnetothermal microenvironment generated by an alternating magnetic field (AMF). The results demonstrate that the scaffolds can be heated by magnetic nanoparticles (NPs) under AMF, which dramatically accelerated scaffold degradation. Especially, magnetic NPs modified by oleic acid with a better interface compatibility exhibit a greater heating efficiency to further facilitate the degradation. Furthermore, the molecular dynamics simulations reveal that the enhanced motion correlation between magnetic NPs and polymer matrix can accelerate the energy transfer. As a proof‐of‐concept, the feasibility of magneto‐controlled degradation for implants is demonstrated, and an optimizing strategy for better heating efficiency of nanomaterials is provided, which may have great instructive significance for clinical medicine. Abstract : The idea of magneto‐controlled degradation by using modified magnetic nanomaterials is proposed and verified in vitro. Moreover, the molecular dynamics simulation is employed to reveal the micro‐mechanism of the enhanced energy transfer. It will provide a new biomedical technology and a potential wearable apparatus for deciding the fate of biodegradable polymer implants with the advantages of portable, noninvasive, and spatiotemporal therapy.