Use of aminoglycoside antibiotics in equine clinical practice; a questionnaire‐based study of current use. Issue 2 (24th October 2020)

• Record Type: Journal Article
• Authors: Redpath, Adam; Hallowell, Gayle D.; Bowen, Ian Mark
• Is Part Of: Veterinary medicine and science. Volume 7:Issue 2(2021)
• Page Start: 279
• Page End: 288
• Publication Date: 2020-10-24
• Subjects: aminoglycosides -- antibiotic resistance -- equine medicine; Veterinary medicine -- Periodicals; Animal Diseases; Veterinary medicine; Periodicals; Periodicals; 636.08905
• DOI: 10.1002/vms3.382
• Languages: English
• ISSNs: 2053-1095

Abstract

Abstract: Veterinary use of the aminoglycoside antibiotics is under increasing scrutiny. This questionnaire‐based study aimed to document the use of aminoglycosides with a particular focus on gentamicin. An online questionnaire was delivered to generalist equine veterinary surgeons and specialists in internal medicine to determine the perceived importance, frequency of use and routes of administration of the aminoglycoside antibiotics. A series of hypothetical scenarios were also evaluated regarding gentamicin. Data were compared to evaluate the impact of the level of specialisation on prescribing practices for different antibiotics using Chi‐squared and Fischer's exact tests. Data were analysed from 111 responses. Gentamicin was commonly used empirically without culture and susceptibility testing. Generalists were more likely to use gentamicin only after susceptibility testing than specialists in a variety of clinical presentations including respiratory diseases, septic peritonitis, acute febrile diarrhoea, cellulitis and contaminated limb wounds ( p < 0.01). Intravenous administration of gentamicin was most common, although inhaled and regional administration of gentamicin and amikacin were also described. Amikacin was most commonly used by intra‐articular administration. Gentamicin was more likely to be used in high‐risk procedures or contaminated surgeries (86% and 74%, respectively) compared with clean surgery (32%; p < 0.0001). Gentamicin was often used perioperatively in horses undergoing exploratory celiotomy and more commonly used in horses undergoing an enterotomy (90%) than without and enterotomy (79%; p = 0.04). Most respondents (86%) used gentamicin at a dose of 6.6 mg/kg in adults, with few changing their dosing strategies based on the presence of sepsis, although higher doses were more reported in foals (7–15 mg/kg) irrespective of the presence of sepsis. Aminoglycosides are widely used in equine practice and use outside current EU marketing authorisations is common. Stewardship of the aminoglycoside antibiotics could be enhanced in both generalists and specialists through the more frequent use of susceptibility testing, regional administration and dose adjustment, especially in foals. Abstract : Gentamicin is the most important and commonly used aminoglycoside used in equine practice, although commonly used for conditions outside its marketing authorisation. Amikacin is the aminoglycoside most commonly used by the intra‐articular or regional route. Dosing of aminoglycosides used in clinical practice could be enhanced through wider use of therapeutic drug monitoring.