Disparate outcomes in nonsmall cell lung cancer by immigration status. (18th March 2021)

• Record Type: Journal Article
• Authors: Chau, Brittney; Ituarte, Philip HG; Shinde, Ashwin; Li, Richard; Vazquez, Jessica; Glaser, Scott; Massarelli, Erminia; Salgia, Ravi; Erhunmwunsee, Loretta; Ashing, Kimlin; Amini, Arya
• Is Part Of: Cancer medicine. Volume 10:Number 8(2021)
• Page Start: 2660
• Page End: 2667
• Publication Date: 2021-03-18
• Subjects: Disparities -- Ethnicity -- Immigrants -- lung cancer -- nationality -- nonsmall cell lung cancer -- NSCLC -- race; 616.994005
• DOI: 10.1002/cam4.3848
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Objective: The purpose of this study was to evaluate overall survival (OS) outcomes by race, stratified by country of origin in patients diagnosed with NSCLC in California. Methods: We performed a retrospective analysis of nonsmall cell lung cancer (NSCLC) patients diagnosed between 2000 and 2012. Race/ethnicity was defined as White (W), Black (B), Hispanic (H), and Asian (A) and stratified by country of origin (US vs. non‐US [NUS]) creating the following patient cohorts: W‐US, W‐NUS, B‐US, B‐NUS, H‐US, H‐NUS, A‐US, and A‐NUS. Three multivariate models were created: model 1 adjusted for age, gender, stage, year of diagnosis and histology; model 2 included model 1 plus treatment modalities; and model 3 included model 2 with the addition of socioeconomic status, marital status, and insurance. Results: A total of 68, 232 patients were included. Median OS from highest to lowest were: A‐NUS (15 months), W‐NUS (14 months), A‐US (13 months), B‐NUS (13 months), H‐US (11 months), W‐US (11 months), H‐NUS (10 months), and B‐US (10 months) ( p < 0.001). In model 1, B‐US had worse OS, whereas A‐US, W‐NUS, B‐NUS, H‐NUS, and A‐NUS had better OS when compared to W‐US. In model 2 after adjusting for receipt of treatment, there was no difference in OS for B‐US when compared to W‐US. After adjusting for all variables (model 3), all race/ethnicity profiles had better OS when compared to W‐US; B‐NUS patients had similar OS to W‐US. Conclusion: Foreign‐born patients with NSCLC have decreased risk of mortality when compared to native‐born patients in California after accounting for treatments received and socioeconomic differences. Abstract : Foreign‐born patients with NSCLC have decreased risk of mortality when compared to native born patients in California after accounting for treatments received and socioeconomic differences.