Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking. (4th March 2021)
- Record Type:
- Journal Article
- Title:
- Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking. (4th March 2021)
- Main Title:
- Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking
- Authors:
- Czyzyk-Krzeska, Maria F.
Meller, Jarek
Landero Figueroa, Julio A.
Plas, David R.
Cunningham, John T. - Abstract:
- ABSTRACT: Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC.
- Is Part Of:
- Molecular & cellular oncology. Volume 8:Number 2(2021)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 8:Number 2(2021)
- Issue Display:
- Volume 8, Issue 2 (2021)
- Year:
- 2021
- Volume:
- 8
- Issue:
- 2
- Issue Sort Value:
- 2021-0008-0002-0000
- Page Start:
- Page End:
- Publication Date:
- 2021-03-04
- Subjects:
- Clear cell renal cell carcinoma -- tobacco smoking -- oxidative phosphorylation -- arsenic -- copper
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2020.1859917 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 16362.xml