It takes three to the DNA damage response tango. (4th March 2021)

• Record Type: Journal Article
• Authors: Schlam-Babayov, Sapir; Ziv, Yael; Shiloh, Yosef
• Is Part Of: Molecular & cellular oncology. Volume 8:Number 2(2021)
• Publication Date: 2021-03-04
• Subjects: Ataxia-telangiectasia -- ATM -- DNA damage response -- PIKKs -- phosphoproteomic; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2021.1881395
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).