Analysis of recurrent hypoglycemic events. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Ma, Chenchen; Qu, Yongming; Fu, Haoda
• Is Part Of: Journal of biopharmaceutical statistics. Volume 31:Issue 1(2021)
• Page Start: 5
• Page End: 13
• Publication Date: 2021-01-02
• Subjects: Gamma frailty -- piecewise negative binomial regression -- sandwich variance estimator; Pharmacy -- Statistical methods -- Periodicals; Drugs -- Testing -- Statistical methods -- Periodicals; Biometry -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacokinetics -- Periodicals; 615.19
• DOI: 10.1080/10543406.2020.1765370
• Languages: English
• ISSNs: 1054-3406

Abstract

ABSTRACT: Hypoglycemia is a major safety concern for diabetic patients. Hypoglycemic events can be modeled based on time to recurrent events or count data. In this article, we evaluated a gamma frailty model with variance estimated by the inverse of observed Fisher information matrix, a gamma frailty model with the sandwich variance estimator, and a piecewise negative binomial regression model. Simulations showed that the sandwich variance estimator performed better when the frailty model is mis-specified, and the piecewise negative binomial regression sometimes fails to converge. All three methods were applied to a dataset from a clinical trial evaluating insulin treatments.