P53 regulates cellular redox state, ferroptosis and metabolism. (4th March 2021)

• Record Type: Journal Article
• Authors: Leu, Julia I-Ju; Murphy, Maureen E.; George, Donna L.
• Is Part Of: Molecular & cellular oncology. Volume 8:Number 2(2021)
• Publication Date: 2021-03-04
• Subjects: Ferroptosis -- p53 -- metabolism -- cysteine modification -- redox signaling; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2021.1877076
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The tumor protein P53 ( TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis.