A rare case of eptifibatide-induced thrombocytopenia. Issue 2 (4th March 2021)

• Record Type: Journal Article
• Authors: Kamar, Khalil; MacDougall, Kira; Alsheikh, Mira; Parylo, Sara; Skaradinskiy, Yevgeniy
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 11:Issue 2(2021)
• Page Start: 269
• Page End: 272
• Publication Date: 2021-03-04
• Subjects: Eptifibatide -- glycoprotein IIb/IIIa receptor antagonist -- thrombocytopenia -- drug-induced thrombocytopenia -- acute coronary syndrome; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2021.1871802
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Eptifibatide is a glycoprotein (GP) IIb/IIIa receptor antagonist, used for the treatment of acute coronary syndrome with high-risk features or ongoing ischemia. Several case reports have described thrombocytopenia as a rare side effect of eptifibatide administration. The exact mechanism remains unclear but may be due to immune destruction of circulating platelets in the peripheral blood. We present the case of acute-onset severe thrombocytopenia in a 76-year-old female undergoing percutaneous coronary intervention.