The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis. (4th March 2021)

• Record Type: Journal Article
• Authors: Ai, Youwei; Yan, Bo; Wang, Xiaodong
• Is Part Of: Molecular & cellular oncology. Volume 8:Number 2(2021)
• Publication Date: 2021-03-04
• Subjects: Ferroptosis -- oxidoreductase -- POR -- CYB5R1 -- lipid peroxidation -- H2O2 -- hydroxyl radicals -- PUFA -- GPX4 -- FSP1; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2021.1881393
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2 O2 ). H2 O2 then reacts with ferrous iron, generating hydroxyl radicals that cause peroxidation of polyunsaturated-fatty-acid chains of membrane phospholipids, resulting in plasma membrane rupture and ferroptosis.