Direct C–H aminocarbonylation of N-heteroarenes with isocyanides under transition metal-free conditions. Issue 13 (19th March 2021)

• Record Type: Journal Article
• Authors: Zhou, Zhong; Ji, Huihui; Li, Qing; Zhang, Qian; Li, Dong
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 13(2021)
• Page Start: 2917
• Page End: 2922
• Publication Date: 2021-03-19
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00245g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A C–C bond forming amide synthesis through direct C–H aminocarbonylation of N -heteroarenes with isocyanides was developed. The reaction was mediated by an inorganic persulfate salt under transition metal-free conditions. Abstract : A C–C bond forming amide synthesis through direct C–H aminocarbonylation of N -heteroarenes with isocyanides was developed. The reaction was mediated by an inorganic persulfate salt under transition metal-free conditions. Mechanistic studies suggested a radical pathway for this reaction without the participation of H2 O and O2 . This method also showed merits of substrate availability, easy operation and atom economy. It provided an efficient route for straightforward synthesis of N -heteroaryl amides.