More than just a barrier: using physical models to couple membrane shape to cell function. Issue 13 (27th January 2021)

• Record Type: Journal Article
• Authors: Frey, Felix; Idema, Timon
• Is Part Of: Soft matter. Volume 17:Issue 13(2021)
• Page Start: 3533
• Page End: 3549
• Publication Date: 2021-01-27
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/d0sm01758b
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : Physical models can help us to infer, from the shape of the outer membrane, which biological processes happen inside the living cell. Abstract : The correct execution of many cellular processes, such as division and motility, requires the cell to adopt a specific shape. Physically, these shapes are determined by the interplay of the plasma membrane and internal cellular driving factors. While the plasma membrane defines the boundary of the cell, processes inside the cell can result in the generation of forces that deform the membrane. These processes include protein binding, the assembly of protein superstructures, and the growth and contraction of cytoskeletal networks. Due to the complexity of the cell, relating observed membrane deformations back to internal processes is a challenging problem. Here, we review cell shape changes in endocytosis, cell adhesion, cell migration and cell division and discuss how by modeling membrane deformations we can investigate the inner working principles of the cell.