Palladium-catalyzed decarbonylative and decarboxylative cross-coupling of acyl chlorides with potassium perfluorobenzoates affording unsymmetrical biaryls. Issue 30 (16th March 2021)

• Record Type: Journal Article
• Authors: Fu, Liyan; You, Jingwen; Nishihara, Yasushi
• Is Part Of: Chemical communications. Volume 57:Issue 30(2021)
• Page Start: 3696
• Page End: 3699
• Publication Date: 2021-03-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc00202c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Palladium-catalyzed cross-coupling of acyl chlorides with potassium perfluorobenzoates to synthesize perfluorinated biaryls has been reported, which realized the first example involving simultaneous decarbonylation and decarboxylation under redox-neutral conditions. Abstract : This paper describes the synthesis of unsymmetrical biaryls by the palladium-catalyzed cross-coupling reaction of acyl chlorides with potassium perfluorobenzoates. This transformation is unique in that it involves simultaneous decarbonylation and decarboxylation under redox-neutral conditions. Compared to conventional cross-coupling protocols for the synthesis of unsymmetrical biaryls, the two reactants in this synthetic strategy can be readily prepared from abundant and inexpensive aromatic carboxylic acids.