A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images. Issue 13 (16th March 2021)

• Record Type: Journal Article
• Authors: Lee, Woonghee; Bobba, Kondapa Naidu; Kim, Jung Young; Park, Hyun; Bhise, Abhinav; Kim, Wanook; Lee, Kiwoong; Rajkumar, Subramani; Nam, Bora; Lee, Kyo Chul; Lee, Sang Hyuk; Ko, Sanghwan; Lee, Hye Jin; Jung, Sang Taek; Yoo, Jeongsoo
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 13(2021)
• Page Start: 2993
• Page End: 2997
• Publication Date: 2021-03-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb02911d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A PEGylated antibody with short PEG linkers was excreted faster to visualize tumors clearly with exceptionally high tumor-to-background ratio in nuclear imaging. Abstract : The prolonged blood circulation of the radiolabeled antibody conjugates is problematic when using immuno-PET imaging due to the increased radiation exposure and longer hospitalization required until sufficient contrast develops. In contrast to the prevailing belief that PEGylation prolongs blood retention time, we observed that a PEGylated antibody with a short PEG8 linker cleared much faster from the blood while maintaining tumor uptake compared to its non-PEGylated counterpart. Breast tumors were clearly visualized with a very high tumor-to-background ratio as early as 24 h after injection in immuno-positron emission tomography (PET) imaging.