The contribution of non-coding regulatory elements to cardiovascular disease. Issue 7 (1st July 2020)

• Record Type: Journal Article
• Authors: Villar, Diego; Frost, Stephanie; Deloukas, Panos; Tinker, Andrew
• Is Part Of: Open biology. Volume 10:Issue 7(2020)
• Publication Date: 2020-07-01
• Subjects: cardiovascular -- gene regulation -- GWAS -- epigenetics -- functional genomics; Biology -- Periodicals; 570
• DOI: 10.1098/rsob.200088
• Languages: English
• ISSNs: 2046-2441

Abstract

Abstract : Abstract : Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-wide association studies across a range of cardiovascular traits and pathologies have highlighted the prevalence of common non-coding genetic variants within candidate loci. Here, we review genetic, epigenomic and molecular approaches to investigate the contribution of non-coding regulatory elements in cardiovascular biology. We then discuss recent insights on the emerging role of non-coding variation in predisposition to cardiovascular disease, with a focus on novel mechanistic examples from functional genomics studies. Lastly, we consider the clinical significance of these findings at present, and some of the current challenges facing the field.