Generalized and orofacial choreoathetosis: a case report of anti-CV2 paraneoplastic syndrome after cardiac arrest. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Broadley, James; Blazé, Richard
• Is Part Of: Neurocase. Volume 27:Issue 1(2021)
• Page Start: 72
• Page End: 75
• Publication Date: 2021-01-02
• Subjects: CV2 -- CRMP5 -- paraneoplastic -- choreoathetosis -- case report; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2020.1866615
• Languages: English
• ISSNs: 1355-4794

Abstract

ABSTRACT: CV2/CRMP5 is the most common antibody accompaniment of paraneoplastic choreoathetosis. We present a case of paraneoplastic choreothetosis with associated cerebellar dysfunction, peripheral neuropathy, and likely dysautonomia. Our patient developed a movement disorder after a cardiopulmonary arrest, which unfortunately masked the true etiology of his symptoms. He was later found to have extensive stage small cell lung cancer, with further evaluation revealing seropositivity for anti-CV2 antibodies. Choreoathetosis is a known sequelae of hypoxic-ischemic brain injury, but clinicians should continue to keep an open mind. The utility of immunotherapy is unclear in these circumstances and many physicians adopt a symptom-based approach.