Elevation of progesterone on the trigger day exerts no carryover effect on live birth in freeze-all cycles. (3rd April 2021)

• Record Type: Journal Article
• Authors: Boynukalin, Fazilet Kubra; Yarkiner, Zalihe; Gultomruk, Meral; Turgut, Niyazi Emre; Ecemis, Selen; Findikli, Necati; Bahceci, Mustafa
• Is Part Of: Gynecological endocrinology. Volume 37:Number 4(2021)
• Page Start: 367
• Page End: 371
• Publication Date: 2021-04-03
• Subjects: Freeze-all -- IVF/ICSI -- trigger day progesterone; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2020.1786510
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Aim: To evaluate the effect of trigger day progesterone (P) levels on live birth in freeze-all cycles. Material and methods: Retrospective analysis of 1034 freeze-all female patients aged <38 years with single blastocyst transfers. Patients with ( n = 268) or without ( n = 766) preimplantation genetic test for aneuploidy (PGT-A) arm were further categorized into three subgroups based on trigger day P levels; low (<0.80 ng/ml), medium (0.8–1.49 ng/ml), and high (≥1.50 ng/ml). Results: Estradiol (E2) levels on trigger day, the number of oocytes retrieved and the number of mature oocytes increased significantly with increasing serum p values in cycles without and with PGT-A arms. Significant correlation was found between E2 levels on trigger day and serum P levels and between the number of total oocytes retrieved and serum P levels Live birth rates were similar in the three subgroups in without PGT-A arm (51%, 52.6%, and 51.5%, respectively; p = .922) and with PGT-A arm (55.1%, 55.1%, and 62.5%, respectively; p = .730). Multivariate regression analysis revealed that trigger day P levels were not significant for live birth. Conclusion: The proposal that trigger day progesterone elevation (PE) exerts a detrimental effect on oocyte and embryo competence has no clinical validity.