Functionalized nanoprobes for in situ detection of telomerase. Issue 31 (23rd March 2021)

• Record Type: Journal Article
• Authors: Yu, Zhengze; Jiang, Fan; Hu, Chenchen; Tang, Bo
• Is Part Of: Chemical communications. Volume 57:Issue 31(2021)
• Page Start: 3736
• Page End: 3748
• Publication Date: 2021-03-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc08412c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Telomerase can maintain the length and stability of telomeres and plays an important role in cell proliferation and differentiation. Based on different materials, various functionalized nanoprobes were developed for in situ telomerase detection. Abstract : Telomerase, a special ribonucleoprotein reverse transcriptase, can maintain the length and stability of telomeres and plays an important role in cell proliferation and differentiation. Due to the distinguishable expression level in normal cells and cancer cells, telomerase has become an important biomarker for cancer diagnosis and prognosis evaluation. Despite major breakthroughs in the field of telomerase detection, the extracts in the cell lysate are still the first choice as the analyte nevertheless, which will bring serious inaccuracies compared with the real intracellular activity. With the development of nanotechnology and nanomaterials, extraordinary progress has been made in telomerase detection by employing different versatile nanoprobes. In this review, we list the superiority of nanoprobes and systematically summarize the applications of nanoprobes in telomerase detection from the aspects of various nanomaterials and discuss the current challenges and potential trends in the future design of nanoprobes.