Direct ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling. Issue 31 (17th March 2021)
- Record Type:
- Journal Article
- Title:
- Direct ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling. Issue 31 (17th March 2021)
- Main Title:
- Direct ligand screening against membrane proteins on live cells enabled by DNA-programmed affinity labelling
- Authors:
- Huang, Yiran
Deng, Yuqing
Zhang, Jianfu
Meng, Ling
Li, Xiaoyu - Abstract:
- Abstract : DNA-programmed affinity labelling (DPAL) enables the screening of chemical compounds against membrane proteins directly on live cells. Abstract : Membrane proteins are important drug targets; however, ligand discovery for membrane proteins is highly challenging due to their hydrophobic nature. We show that membrane proteins may be specifically labelled with a DNA tag by DNA-programmed affinity labelling (DPAL), thereby enabling the screening of chemical compounds against membrane proteins directly on live cells.
- Is Part Of:
- Chemical communications. Volume 57:Issue 31(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 31(2021)
- Issue Display:
- Volume 57, Issue 31 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 31
- Issue Sort Value:
- 2021-0057-0031-0000
- Page Start:
- 3769
- Page End:
- 3772
- Publication Date:
- 2021-03-17
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc00961c ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 16345.xml