Rapid, wide-field, high quality laser speckle angiography for retinal and choroidal vessels. (20th April 2021)

• Record Type: Journal Article
• Authors: Feng, Ximeng; Zou, Da; Hu, Yicheng; Huang, Zhiyu; Gu, Zheng; Zhou, Cuanqing; Liu, Gangjun; Ren, Qiushi; Lu, Yanye
• Is Part Of: Laser physics letters. Volume 18:Number 5(2021)
• Publication Date: 2021-04-20
• Subjects: laser speckle contrast imaging -- retina -- perfusion image; Lasers -- Periodicals; Physics -- Periodicals; 621.366
• DOI: 10.1088/1612-202X/abf5ce
• Languages: English
• ISSNs: 1612-2011

Abstract

Abstract: Laser speckle contrast imaging has been widely used for quantifying blood perfusion. In this letter, we propose a rapid, wide-field laser speckle angiography technique for noninvasive imaging of retinal and choroidal vessels. The field of view (FOV) reaches ∼50 ∘ while the acquisition time was less than 1 s. Larger FOV (∼90 ∘ ) can be further improved by mosaicking. The results were comparatively studied with optical coherence tomography angiography and fundus fluorescence angiography. The low-cost technology can obtain wide-field fundus vascular and perfusion images less than 1 s. This technology is more suitable for optic disc and choroidal vasculature imaging. In addition, blood flow dynamic information such as pulsation can be provided by this technique.