Chemical control of multidomain acetyltransferase activity. Issue 4 (15th April 2021)

• Record Type: Journal Article
• Authors: Lieberman, Whitney K.; Jing, Yihang; Meier, Jordan L.
• Is Part Of: Cell chemical biology. Volume 28:Issue 4(2021)
• Page Start: 433
• Page End: 435
• Publication Date: 2021-04-15
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2021.03.015
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : Chromatin-modifying lysine acetyltransferases employ multiple protein domains to regulate transcription. In this issue, Vannam et al. (2021) describe dCBP-1, a small molecule degrader of the multidomain acetyltransferases EP300 and CREBBP. This provides a new tool for interrogating EP300/CREBBP function and also suggests a strategy for pharmacological differentiation of acetyltransferase paralogs. Abstract : Chromatin-modifying lysine acetyltransferases employ multiple protein domains to regulate transcription. In this issue, Vannam et al. describe dCBP-1, a small molecule degrader of the multidomain acetyltransferases EP300 and CREBBP. This new tool for interrogating EP300/CREBBP function also suggests a strategy for pharmacological differentiation of acetyltransferase paralogs.