Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events. (April 2021)

• Record Type: Journal Article
• Authors: Allen, Jeffrey R.; Strader, Lucia C.
• Is Part Of: Current opinion in cell biology. Volume 69(2021)
• Page Start: 136
• Page End: 141
• Publication Date: 2021-04
• Subjects: Plant biology -- Nucleocytoplasmic partitioning -- Phytohormone -- Environmental signaling -- Biotic stress; Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2021.01.006
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract: The nucleus is the site of transcription events — compartmentalization of transcription in eukaryotes allows for regulated access to chromatin. The nucleopore, a complex of many intrinsically disorder proteins, acts as the gatekeeper for nuclear entry and exit, and receptors for nuclear localization signals and nuclear export signals interact with both cargo and nucleopore components to facilitate this movement. Thus, regulated occlusion of the nuclear localization signal or nuclear export signal, tethering of proteins, or sequestration in biomolecular condensates can be used to regulate nucleocytoplasmic partitioning. In plants, regulated nucleocytoplasmic partitioning is a key mechanism to regulate signaling pathways, including those involved in various phytohormones, environmental stimuli, and pathogen responses. Highlights: Altering protein localization from nuclear to cytoplasmic regulates signaling. The multiprotein nuclear complex gatekeeps traffic between the nucleus and cytoplasm. In Arabidopsis, nucleocytoplasmic partitioning regulates important signaling processes. Biomolecular condensates and tethering can be used to regulate the localization of proteins.