Noise buffering by biomolecular condensates in glucose sensing. (April 2021)

• Record Type: Journal Article
• Authors: Simpson-Lavy, Kobi; Kupiec, Martin
• Is Part Of: Current opinion in cell biology. Volume 69(2021)
• Page Start: 1
• Page End: 6
• Publication Date: 2021-04
• Subjects: SNF1 -- Amyloid -- Liquid drop -- Protein condensation -- Protein aggregation -- Carbon source -- Metabolic regulation -- Chaperones -- Glucose; Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2020.12.002
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract: Many cellular processes involve buffering mechanisms against noise to enhance state stability. Such processes include the cell cycle and the switch between respiration and fermentation. In recent years, protein aggregation/condensation has emerged as an important regulatory mechanism. In this article, we examine the regulation of Std1, an activator of the Snf1/AMPK kinase, by sequestration into foci of liquid drops, and how foci of metabolic signaling and enzymatic proteins are regulated by chaperones, anti-aggregases and by phosphorylation.