Stereoselective Construction of Nitrile‐Substituted Cyclopropanes from 2‐Substituted Ethenesulfonyl Fluorides via Carbon‐Sulfur Bond Cleavage. Issue 19 (13th August 2019)

• Record Type: Journal Article
• Authors: Liu, Hao; Moku, Balakrishna; Li, Fei; Ran, Jiabing; Han, Jinsong; Long, Sihui; Zha, Gao‐Feng; Qin, Hua‐Li
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 19(2019)
• Page Start: 4596
• Page End: 4601
• Publication Date: 2019-08-13
• Subjects: Cyclopropanation -- Ethenesulfonyl fluorides -- Diastereoselectivity -- Nitrile-substituted; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900635
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The intermolecular cyclopropanation of 2‐aryl and 2‐styryl substituted ethenesulfonyl fluorides with active cyano‐containing methylene compounds was described. This reaction proceeds via carbon‐sulfur bond cleavage under metal‐free conditions in up to 99% yield, affording a variety of nitrile‐substituted cyclopropanes with high diastereoselectivity. Abstract :