Diversification of Peptidomimetics and Oligopeptides through Microwave‐Assisted Rhodium(III)‐Catalyzed Intramolecular Annulation. Issue 19 (13th August 2019)

• Record Type: Journal Article
• Authors: Song, Liangliang; Tian, Guilong; Blanpain, Anna; Van Meervelt, Luc; Van der Eycken, Erik V.
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 19(2019)
• Page Start: 4442
• Page End: 4447
• Publication Date: 2019-08-13
• Subjects: Annulation -- C−H Activation -- Rhodium -- Peptidomimetic -- Peptide; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900550
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A chemoselective rhodium(III)‐catalyzed cascade annulation for the construction of the indolizinone and quinolizinone scaffolds is developed. Diversification of peptidomimetics and oligopeptides is achieved in a rapid and step‐economical manner through the combination of Ugi reaction and microwave‐assisted rhodium(III)‐catalyzed intramolecular annulation via C( sp 2 )‐H activation without installing a directing group. Abstract :