Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand, foot, and mouth disease in Yunnan, Southwest China, during 2009‐2015. Issue 1 (9th October 2018)

• Record Type: Journal Article
• Authors: Zhang, Ming; Zhao, Yilin; Zhang, Haihao; Lin, Keqin; Liu, Hongbo; Zhang, Jie; Ding, Lisha; Huang, Xiaoqin; Yang, Zhaoqing; Ma, Shaohui
• Is Part Of: Journal of medical virology. Volume 91:Issue 1(2019)
• Page Start: 155
• Page End: 160
• Publication Date: 2018-10-09
• Subjects: characterization -- complete genome -- Coxsackievirus A16 -- phylogenetic analysis; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25297
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Coxsackievirus A16 (CV‐A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV‐A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV‐A16 were predominantly circulating the region with B1b the predominant strain in recent years. The mean rate of nucleotide substitution based on the VP1 gene sequence was 4.545 × 10 −3 substitution per site per year from 2009 to 2015. These results may help in understanding the genetic diversity of CV‐A16 and develop a CV‐A16 vaccine.