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Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV. Issue 1 (9th September 2019)
Record Type:
Journal Article
Title:
Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV. Issue 1 (9th September 2019)
Main Title:
Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV
Highlights: People living with HIV do not achieve an optional immune reconstitution despite the sustained virologic suppression. Circulating CD4 T cells fail to replenish their lymphoid tissue counterparts in people living with HIV. Irrespective of ART, coffin hyperactivation and impaired T cell mobility persist in people living with HIV. Cofilin may represent a novel therapeutic target to restore T cell mobility in people living with HIV.