Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals. (16th February 2017)

• Record Type: Journal Article
• Authors: Zanni, Markella V.; Toribio, Mabel; Wilks, Moses Q.; Lu, Michael T.; Burdo, Tricia H.; Walker, Joshua; Autissier, Patrick; Foldyna, Borek; Stone, Lauren; Martin, Amanda; Cope, Fred; Abbruzzese, Bonnie; Brady, Thomas; Hoffmann, Udo; Williams, Kenneth C.; El-Fakhri, Georges; Grinspoon, Steven K.
• Is Part Of: Journal of infectious diseases. Volume 215:Number 8(2017:Apr. 15)
• Page Start: 1264
• Page End: 1269
• Publication Date: 2017-02-16
• Subjects: HIV-associated cardiovascular disease -- arterial inflammation -- atherosclerosis.; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix095
• Languages: English
• ISSNs: 0022-1899

Abstract

Summary: In this proof-of-concept study, we present the first-in-human data suggesting that systemic administration of technetium Tc 99m tilmanocept ( 99m Tc-tilmanocept) enables noninvasive quantification of arterial CD206 + macrophages. Application of this macrophage-specific molecular imaging strategy highlights high-level aortic 99m Tc-tilmanocept uptake in human immunodeficiency virus and a relationship to noncalcified aortic plaque. Abstract: Background: The ability to noninvasively assess arterial CD206 + macrophages may lead to improved understanding of human immunodeficiency virus (HIV)–associated cardiovascular disease. Methods: We trialed a novel macrophage-specific arterial imaging technique. Results: We demonstrated colocalization between technetium Tc 99m tilmanocept ( 99m Tc-tilmanocept) and CD206 + macrophages ex vivo. In vivo application of 99m Tc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99m Tc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non–HIV-infected subjects ( P = .009). Among all subjects, aortic high-level 99m Tc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status. Conclusion: These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV. Clinical Trials Registration: NCT02542371