Association of Human Immunoglobulin G1 Heavy Chain Variants With Neutralization Capacity and Antibody-Dependent Cellular Cytotoxicity Against Human Cytomegalovirus. (27th July 2016)

• Record Type: Journal Article
• Authors: Vietzen, Hannes; Görzer, Irene; Puchhammer-Stöckl, Elisabeth
• Is Part Of: Journal of infectious diseases. Volume 214:Number 8(2016:Oct. 15)
• Page Start: 1175
• Page End: 1179
• Publication Date: 2016-07-27
• Subjects: IgG1 -- GM variants -- human cytomegalovirus -- neutralization -- NK-cell activation; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiw315
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Human cytomegalovirus (HCMV) infection is limited by HCMV-specific antibody functions. Here the association between the genetic marker (GM) 3/17 variants in the immunoglobulin G1 (IgG1) heavy chain constant region, virus neutralization, and natural killer (NK)–cell activation was investigated. In 100 HCMV-seropositive individuals, the GM3/17 polymorphism, serum 50% HCMV antibody neutralization titer (NT50 ), and in vitro HCMV-specific antibody NK-cell activation were assessed. The HCMV NT50 was higher in heterozygous GM3/17 persons than in GM3/3 persons ( P = .0276). Furthermore, individuals expressing GM3/17 exhibited significantly higher NK-cell activation than persons carrying GM3/3 ( P < .0001) or GM17/17 ( P = .0095). Thus, persons expressing GM3/17 have potentially a selective advantage in HCMV defense.