Towards hybrid biocompatible magnetic rHuman serum albumin-based nanoparticles: use of ultra-small (CeLn)3/4+ cation-doped maghemite nanoparticles as functional shell. (5th January 2015)

• Record Type: Journal Article
• Authors: Israel, Liron L; Kovalenko, Elena I; Boyko, Anna A; Sapozhnikov, Alexander M; Rosenberger, Ina; Kreuter, Jörg; Passoni, Lorena; Lellouche, Jean-Paul
• Is Part Of: Nanotechnology. Volume 26:Number 4(2015)
• Publication Date: 2015-01-05
• Subjects: lanthanide coordination chemistry -- maghemite nanoparticles -- human serum albumin; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/0957-4484/26/4/045601
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Human serum albumin (HSA) is a protein found in human blood. Over the last decade, HSA has been evaluated as a promising drug carrier. However, not being magnetic, HSA cannot be used for biomedical applications such as magnetic resonance imaging (MRI) and magnetic drug targeting. Therefore, subsequent composites building on iron oxide nanoparticles that are already used clinically as MRI contrast agents are extensively studied. Recently and in this context, innovative fully hydrophilic ultra-small CAN-stabilized maghemite ((CeLn ) 3/4+ - γ -Fe2 O3 ) nanoparticles have been readily fabricated. The present study discusses the design, fabrication, and characterization of a dual phase hybrid core (rHSA)-shell ((CeLn ) 3/4+ - γ -Fe2 O3 NPs) nanosystem. Quite importantly and in contrast to widely used encapsulation strategies, rHSA NP surface-attached (CeLn ) 3/4+ - γ -Fe2 O3 NPs enabled to exploit both rHSA (protein functionalities) and (CeLn ) 3/4+ - γ -Fe2 O3 NP surface functionalities (COOH and ligand L coordinative exchange) in addition to very effective MRI contrast capability due to optimal accessibility of H2 O molecules with the outer magnetic phase. Resulting hybrid nanoparticles might be used as a platform modular system for therapeutic (drug delivery system) and MR diagnostic purposes.