REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer. (September 2019)

• Record Type: Journal Article
• Authors: Lievens, Yolande; van Eijkeren, Marc; Vandecasteele, Katrien; Elhamin, Elhaseen; Ost, Piet; Fonteyne, Valérie; Swimberghe, Martijn; Deseyne, Pieter; De Neve, Wilfried; Duprez, Fréderic; Mareel, Marcus; Monten, Chris; Van Greveling, Annick; Vercauteren, Tom; Paelinck, Leen; Defraene, Gilles; Aerts, Rita; Arredouani, Soumia; Lambrecht, Maarten; Vanneste, Ben; Draghici, Roxana; Giordano, Frank; Herskind, Carsten; Veldwijk, Marlon; Helmbold, Irmgard; Giesche, Ulrich; Stegmaier, Petra; Weiß, Christian; Blaschke, Thomas; Neu, Burkhard; Lozza, Laura; Avuzzi, Barbara; Morlino, Sara; Sangalli, Claudia; Franceschini, Marzia; Rodriguez-Lage, Belina; Fernández-Tajes, Juan; Fuentes-Rios, Olivia; Domínguez-Rios, Isabel; Fajardo-Paneque, Irene; Sosa-Fajardo, Paloma; Torrado-Moya, Laura; Ramos-Albiac, Mónica; Giraldo, Alexandra; Altabas, Manolo; Piqué-Leiva, Bibiana; García-Relancio, David; Seoane-Ramallo, Alejandro; Lavers, Samuel; Wright, Simon; Dobbelaere, Hannah; Appleton, Donna; Kaushik, Monika; Kenny, Frances; Khout, Hazem; Krupa, Jaroslaw; Lambert, Kelly V.; Pilgrim, Simon; Shokuhi, Sheila; Valassiadou, Kalliope; Aznar-Garcia, Luis; Boiangui, Ion; Kancherla, Kiran; Kent, Christopher; Sampson, Kufre; Osman, Ahmed; Sridhar, Thiagarajan; Vasanthan, Subramaniam; Faivre-Finn, Corinne; Harrop, Victoria; Keni, Manjusha; Foweraker, Karen; Pascoe, Abigail; Esler, Claire; Stock, Richard; Green, Sheryl; Golchin, Ava; Li, William; Seibold, Petra; Webb, Adam; Aguado-Barrera, Miguel E.; Azria, David; Bourgier, Celine; Brengues, Muriel; Briers, Erik; Bultijnck, Renée; Calvo-Crespo, Patricia; Carballo, Ana; Choudhury, Ananya; Cicchetti, Alessandro; Claßen, Johannes; Delmastro, Elena; Dunning, Alison M.; Elliott, Rebecca M.; Fachal, Laura; Farcy-Jacquet, Marie-Pierre; Gabriele, Pietro; Garibaldi, Elisabetta; Gómez-Caamaño, Antonio; Gutiérrez-Enríquez, Sara; Higginson, Daniel S.; Johnson, Kerstie; Lobato-Busto, Ramón; Mollà, Meritxell; Müller, Anusha; Payne, Debbie; Peleteiro, Paula; Post, Giselle; Rancati, Tiziana; Rattay, Tim; Reyes, Victoria; Rosenstein, Barry S.; De Ruysscher, Dirk; De Santis, Maria Carmen; Schäfer, Jörg; Schnabel, Thomas; Sperk, Elena; Symonds, R. Paul; Stobart, Hilary; Taboada-Valladares, Begoña; Talbot, Christopher J.; Valdagni, Riccardo; Vega, Ana; Veldeman, Liv; Ward, Tim; Weißenberger, Christian; West, Catharine M.L.; Chang-Claude, Jenny;
• Is Part Of: Radiotherapy and oncology. Volume 138(2019)
• Page Start: 59
• Page End: 67
• Publication Date: 2019-09
• Subjects: B breast cancer patients -- BCCT.core Breast Cancer Conservation Treatment.cosmetic results -- BMI body mass index -- BR23 breast module of EORTC QLQ -- CTCAE common terminology criteria for adverse effects -- DICOM Digital Imaging and Communications in Medicine -- DVH dose–volume histogram -- EBRT External beam radiotherapy -- EORTC European Organisation for Research and Treatment of Cancer -- GI gastrointestinal -- GPAQ Global Physical Activity Questionnaire -- GTV gross tumour volume -- GU genito-urinary -- HDR high dose rate brachytherapy -- IMRT intensity modulated radiotherapy -- L lung cancer patients -- LDR low dose rate brachytherapy -- LiH Lithium Heparin -- MD medical doctor -- MFI Multidimensional Fatigue Inventory -- QoL quality-of-life -- P prostate cancer patients -- PSA prostate specific antigen -- RILA radiation-induced lymphocyte assay -- RR relative risk -- RT radiotherapy -- SNP single nucleotide polymorphism -- TURP transurethral resection of the prostate -- VMAT Volumetric Arc Therapy; Late radiotherapy side effects -- Biomarkers -- Prediction models -- Breast cancer -- Prostate cancer -- Lung cancer; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2019.04.034
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: The international multi-centre REQUITE study. 4438 breast, prostate or lung cancer patients undergoing radiotherapy. Prospective standardised data and sample collection. Validating predictive models and biomarkers for radiotherapy toxicity. An accessible real-world resource for the radiotherapy community. Abstract: Purpose: REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data. Methods: An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially curable radiotherapy. Radiotherapy was prescribed according to local regimens, but centres used standardised data collection forms. Pre-treatment blood samples were collected. Patients were followed for a minimum of 12 (lung) or 24 (breast/prostate) months and summary descriptive statistics were generated. Results: The study recruited 2069 breast (99% of target), 1808 prostate (86%) and 561 lung (51%) cancer patients. The centralised, accessible database includes: physician- (47, 025 forms) and patient- (54, 901) reported outcomes; 11, 563 breast photos; 17, 107 DICOMs and 12, 684 DVHs. Imputed genotype data are available for 4223 patients with European ancestry (1948 breast, 1728 prostate, 547 lung). Radiation-induced lymphocyte apoptosis (RILA) assay data are available for 1319 patients. DNA ( n = 4409) and PAXgene tubes ( n = 3039) are stored in the centralised biobank. Example prevalences of 2-year (1-year for lung) grade ≥2 CTCAE toxicities are 13% atrophy (breast), 3% rectal bleeding (prostate) and 27% dyspnoea (lung). Conclusion: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers. Patient summary: Up to half of cancer patients undergo radiation therapy and irradiation of surrounding healthy tissue is unavoidable. Damage to healthy tissue can affect short- and long-term quality-of-life. Not all patients are equally sensitive to radiation "damage" but it is not possible at the moment to identify those who are. REQUITE was established with the aim of trying to understand more about how we could predict radiation sensitivity. The purpose of this paper is to provide an overview and summary of the data and material available. In the REQUITE study 4400 breast, prostate and lung cancer patients filled out questionnaires and donated blood. A large amount of data was collected in the same way. With all these data and samples a database and biobank were created that showed it is possible to collect this kind of information in a standardised way across countries. In the future, our database and linked biobank will be a resource for research and validation of clinical predictors and models of radiation sensitivity. REQUITE will also enable a better understanding of how many people suffer with radiotherapy toxicity.