Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms. (October 2019)

• Record Type: Journal Article
• Authors: Luo, Chuanhong; Xu, Xiaorong; Wei, Xichuan; Feng, Wuwen; Huang, Haozhou; Liu, Haiyan; Xu, Runchun; Lin, Junzhi; Han, Li; Zhang, Dingkun
• Is Part Of: Pharmacological research. Volume 148(2019)
• Publication Date: 2019-10
• Subjects: 5-HT 5-hydroxyserotonin -- DA dopamine -- GABA gamma-aminobutyric acid -- ATP adenosine triphosphate -- ROS reactive oxygen species -- BLA blood lactic acid -- BUN blood urea nitrogen -- ICF idiopathic chronic fatigue -- CFS chronic fatigue syndrome -- TNF-α Tumor necrosis factor – alpha -- IL-1β interleukin-1 -- IL-6 interleukin-6 -- HPA axis Hypothalamic-pituitary-adrenal axis -- TRP tryptophan -- BCAAs branched chain amino acids -- NF-κB the master immune transcription factor nuclear factor kappa B -- CRF cancer-related fatigue -- AMPK amp-dependent protein kinase -- mTOR rapamycin target protein -- PGC-1α peroxisome proliferator-activated receptor gamma coactivator 1alpha -- TG triglyceride -- LDH lactate dehydrogenase -- CK creatine kinase -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- MDA malondialdehyde -- SOD superoxide dismutase -- GSH-Px glutathione peroxidase -- CAT catalase -- CK creatine kinase -- PKA protein kinase A -- SIRT1 sirtuin 1 -- GLUT4 Glucose transporter 4 -- NRF2 nuclear respiratory factor2 -- Kelch-like ECH-related protein 1 Keap1 -- GSR glutathione reductase -- HO-1 heme oxygenase-1 -- TPH2 tryptophan hydroxylase-2 -- 5-HT1B serotoninergic Type 1B -- TFAM transcription factor A -- NADPH nicotinamide adenine dinucleotide phosphate oxidase -- HSPs the heat shock proteins -- MMP-9 matrix metalloproteinase-9 -- SD sprague-Dawley; Isoquercitrin (PubChem CID: 5280804) -- Epicatechin (PubChem CID: 72276) -- (+)-catechin (PubChem CID: 9064) -- Kaempferol (PubChem CID: 5280863) -- Ferulic acid (PubChem CID: 445858) -- Chlorogenic acid (PubChem CID: 1794427) -- Anthocyanins (PubChem CID: 145858) -- Resveratrol (PubChem CID: 445154) -- Rutin (PubChem CID: 5280805) -- Troxerutin (PubChem CID: 5486699) -- Quercetin (PubChem CID: 5280343) -- Gallic acid (PubChem CID: 370) -- Ellagic acid (PubChem CID: 5281855) -- Scopoletin (PubChem CID: 5280460) -- Caffeic acid (PubChem CID: 689043) -- Chlorogenic acid (PubChem CID: 1794427) -- Luteolin (PubChem CID: 5280445) -- Epigallocatechin gallate (PubChem CID: 65064) -- Epigallocatechin (PubChem CID: 72277) -- Epicatechin gallate (PubChem CID: 107905) -- Buddlenol E (PubChem CID: 50909266) -- Ginsenoside Rb1 (PubChem CID: 9898279) -- 20(S)-Ginsenoside Rg3 (PubChem CID: 9918693) -- 20(R)-Ginsenoside Rg3 (PubChem CID: 46887680) -- Ginsenoside Ro (PubChem CID: 11815492) -- Eleutheroside E (PubChem CID: 71312557) -- Ursolic acid (PubChem CID: 64945) -- Tanshinone IIA (PubChem CID: 164676) -- Salidroside (PubChem CID: 159278) -- Verbascoside (PubChem CID: 5281800) -- Cordycepin (PubChem CID: 6303) -- Schisandrin (PubChem CID: 23915); Natural medicines -- Fatigue -- Bioactive components -- Mechanism; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.104409
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms Abstract: It is a common phenomenon that people are in a sub-health condition and facing "unexplained fatigue", which seriously affects their health, work efficiency and quality of life. Meanwhile, fatigue is also a common symptom of many serious diseases such as HIV/AIDS, cancer, and schizophrenia. However, there are still no official recommendations for the treatment of various forms of fatigue. Some traditional natural medicines are often used as health care products, such as ginseng, Cordyceps militaris (L.ex Fr.Link) and Rhodiola rosea L., and these have been reported to have specific anti-fatigue effects with small toxic and side effects and rich pharmacological activities. It may be promising treatment strategy for sub-health. In this review, we first outline the generation of fatigue. Furthermore, we put emphasis on the anti-fatigue mechanism, bioactive components, and clinic trials of natural medicines, which will contribute to the development of potential anti-fatigue agents and open up novel treatments for sub-health.