The resting-brain of obsessive–compulsive disorder. (30th August 2019)

• Record Type: Journal Article
• Authors: Moreira, Pedro Silva; Marques, Paulo; Magalhães, Ricardo; Esteves, Madalena; Sousa, Nuno; Soares, José Miguel; Morgado, Pedro
• Is Part Of: Psychiatry research. Volume 290(2019)
• Page Start: 38
• Page End: 41
• Publication Date: 2019-08-30
• Subjects: Obsessive–compulsive disorder -- Resting-state networks -- FMRI; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2019.06.008
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: We compared functional connectivity between 40 OCD and 40 healthy individuals. OCD patients had reduced connectivity within visual and sensorimotor networks. OCD patients had increased connectivity between default-mode and cerebellar networks. OCD patients had decreased connectivity between sensorial networks. Connectivity between these networks may modulate the manifestation of mood states. Abstract: Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients' daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.