Metabolic syndrome is associated to high-sensitivity cardiac troponin T elevation. (17th February 2019)

• Record Type: Journal Article
• Authors: Milwidsky, Assi; Fisher, Eyal; Brzezinski, Rafael Y.; Ehrenwald, Michal; Shefer, Gabi; Stern, Naftali; Shapira, Itzhak; Zeltser, David; Rosenbaum, Zach; Greidinger, Dahlia; Berliner, Shlomo; Shenhar-Tsarfaty, Shani; Rogowski, Ori
• Is Part Of: Biomarkers. Volume 24:Number 2(2019)
• Page Start: 153
• Page End: 158
• Publication Date: 2019-02-17
• Subjects: Troponin-T -- metabolic syndrome -- cardiovascular risk -- sub-clinical myocardial injury -- obesity -- diabetes; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2018.1528630
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Introduction: Metabolic syndrome (MetS) and high-sensitivity cardiac troponin T (hs-TnT) are associated with higher risk for cardiovascular diseases (CVD). Our aim was to assess the relation between hs-TnT elevation and MetS in a general population sample. Materials and methods: Individuals participating in an annual health survey program between 2010 and 2016 were included in the study. Blood samples including hs-TnT levels were collected. The study population was divided into three groups based on hs-TnT levels – undetectable (<5 ng/L), intermediate (5–14 ng/L) and elevated (>14 ng/L). Results: A total of 5994 subjects were included in the study, the mean age was 48.5 and 4336 (72%) were males. Compared with subjects with undetectable hs-TnT the prevalence of MetS was higher in those with detectable and elevated levels – 392 (10%) vs. 270 (15%) and 51 (33%), respectively ( p < 0.001). In a multivariate model adjusted for age, gender and multiple co-morbidities, the number of MetS components and presence of MetS were significantly associated with an increased risk for detectable hs-TnT levels (OR = 1.02 {for each component}; 95% CI [1.00–1.05], p = 0.04) and (OR = 1.13; 95% CI [1.07–1.2], p < 0.001) respectively. Only the waist, glucose and hypertension components of the MetS were significantly associated with elevated troponin. Conclusions: The MetS and its distinct components have a cumulative impact on hs-TnT levels in apparently healthy subjects.