The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb. (21st April 2017)

• Record Type: Journal Article
• Authors: Bibby, Jack; Saidu, Yauba; Umesi, Ama; Moneke-Anyanwoke, Ngozi; Bashorun, Adedapo O; Hydara, Mariama Badjie; Adigweme, Ikechukwu; Adetifa, Jane U; Okoye, Michael; Roberts, Elishia; Clemens, Ralf; Bandyopadhyay, Ananda S; Muhammad, Abdul K; Mulwa, Sarah; Royals, Michael; Jarrahian, Courtney; Jeffries, David; Kampmann, Beate; Clarke, Ed
• Is Part Of: Clinical infectious diseases. Volume 65:Number 5(2017)
• Page Start: 851
• Page End: 854
• Publication Date: 2017-04-21
• Subjects: polio -- inactivated poliovirus vaccine -- intradermal; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/cix381
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The immunogenicity of fractional (one-fifth, 0.1 mL) intradermal doses of the inactivated poliovirus vaccine (ID fIPV) is positively correlated with the size of the intradermal fluid bleb. Training of vaccinators for campaign and routine ID fIPV administration should focus on generating an 8- to 10-mm bleb with each injection. Clinical Trials Registration: NCT01847872