Potential role of PM2.5 in melanogenesis. (November 2019)

• Record Type: Journal Article
• Authors: Peng, Fen; Tsuji, Gaku; Zhang, Jian-zhong; Chen, Zhou; Furue, Masutaka
• Is Part Of: Environment international. Volume 132(2019)
• Publication Date: 2019-11
• Subjects: Particulate matter 2.5 -- Aryl hydrocarbon receptor -- Reactive oxygen species -- Melanogenesis -- Hyperpigmentation; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2019.105063
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Ambient particulate matter 2.5 (PM2.5 ) is one of the main components of air pollutants, which can absorb many polycyclic aromatic hydrocarbons and metals. The effect of PM2.5 on human skin and its biological significance in skin homeostasis remain incompletely understood. Previous studies demonstrated that PM2.5 can activate aryl hydrocarbon receptor (AhR), generate reactive oxygen species, and induce skin inflammation. These processes may be involved in melanocyte homeostasis and melanogenesis. We hypothesize that AhR signaling may be responsible for PM2.5 -related hyperpigmentation.