How T cells recognize lipids as antigens. (April 2009)
- Record Type:
- Journal Article
- Title:
- How T cells recognize lipids as antigens. (April 2009)
- Main Title:
- How T cells recognize lipids as antigens
- Authors:
- De Libero, Gennaro
- Abstract:
- T lymphocytes recognize lipid antigens as complexes formed by lipids with CD1 antigen-presenting molecules. These complexes are formed within antigen-presenting cells after lipid internalization and their stability contributes to lipid immunogenicity. Immunogenic lipids are amphiphatic structures that insert the hydrophobic tails within the antigen-binding pockets of CD1 molecules and leave their hydrophilic moieties exposed for interaction with T-cell receptors. Minimal variations in both parts influence T-cell recognition, which demonstrates a high grade of specificity. Presentation of lipid antigens requires their efficient internalization, traffic to endosomal compartments where CD1 molecules are encountered, extraction from the membrane, and insertion into CD1 lipid-binding pockets. This article reviews how these events occur and how they are regulated.
- Is Part Of:
- Clinical lipidology. Volume 4:Number 2(2009)
- Journal:
- Clinical lipidology
- Issue:
- Volume 4:Number 2(2009)
- Issue Display:
- Volume 4, Issue 2 (2009)
- Year:
- 2009
- Volume:
- 4
- Issue:
- 2
- Issue Sort Value:
- 2009-0004-0002-0000
- Page Start:
- 189
- Page End:
- 203
- Publication Date:
- 2009-04
- Subjects:
- autoimmunity -- CD1 -- glycosphingolipids -- infection -- lipid antigens -- metabolism -- T cells -- traffic -- vaccines
Lipids -- Periodicals
616.3997 - Journal URLs:
- http://www.futuremedicine.com/loi/clp ↗
http://www.tandfonline.com/toc/tlip20/current ↗
http://www.futuremedicine.com/ ↗ - DOI:
- 10.2217/clp.09.10 ↗
- Languages:
- English
- ISSNs:
- 1758-4299
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3286.297900
British Library DSC - BLDSS-3PM
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