Developing an international network for Alzheimer's research: the Dominantly Inherited Alzheimer Network. (October 2012)

• Record Type: Journal Article
• Authors: Morris, John C; Aisen, Paul S; Bateman, Randall J; Benzinger, Tammie LS; Cairns, Nigel J; Fagan, Anne M; Ghetti, Bernardino; Goate, Alison M; Holtzman, David M; Klunk, William E; McDade, Eric; Marcus, Daniel S; Martins, Ralph N; Masters, Colin L; Mayeux, Richard; Oliver, Angela; Quaid, Kimberly; M Ringman, John; Rossor, Martin N; Salloway, Stephen; Schofield, Peter R; Selsor, Natalie J; Sperling, Reisa A; Weiner, Michael W; Xiong, Chengjie; Moulder, Krista L; Buckles, Virginia D
• Is Part Of: Clinical investigation. Volume 2:Number 10(2012)
• Page Start: 975
• Page End: 984
• Publication Date: 2012-10
• Subjects: Alzheimer's disease -- amyloid-β -- APP -- autosomal dominant -- biomarkers of Alzheimer's disease -- preclinical Alzheimer's disease -- PSEN1 -- PSEN2; Drugs -- Testing -- Periodicals; Drug development -- Periodicals; Clinical trials -- Periodicals; 615.580724
• DOI: 10.4155/cli.12.93
• Languages: English
• ISSNs: 2041-6806

Abstract

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer's Disease (AD) Centers that are conducting a multifaceted prospective biomarker study in individuals at risk for autosomal dominant AD. The DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic autosomal dominant AD mutation carriers and their noncarrier family members to determine the pathochronology of clinical, cognitive, neuroimaging and fluid biomarkers of AD. This article describes the structure, implementation and underlying principles of the DIAN, as well as the demographic features of the initial DIAN cohort.