Improving outcomes in germ cell cancers using miRNA. (June 2021)

• Record Type: Journal Article
• Authors: Conduit, Ciara; Tran, Ben
• Is Part Of: Therapeutic advances in medical oncology. Volume 13(2021)
• Publication Date: 2021-06
• Subjects: blood-based biomarker -- germ cell tumour -- molecular oncology -- predictive biomarker -- prognostic biomarker; Oncology -- Periodicals; Cancer -- Treatment -- Periodicals; 616.994005
• DOI: 10.1177/17588359211027826
• Languages: English
• ISSNs: 1758-8340

Abstract

Owing to advances in treatment paradigms across the last five decades, testicular cancer is now eminently curable. However, current serum tumour and imaging biomarkers lack adequate sensitivity, specificity, and predictive value. Subsequently, their utility in detecting active malignancy and informing treatment decisions is minimal in a large proportion of men with testicular cancer. Micro-ribonucleic acids (miRNA), pertinently miR-371a-3p, offer a new tool, which based on early data, appears to fill many of the gaps that existing biomarkers leave. This paper reviews the evolution of the technology, potential limitations, and discusses the clinical relevance of miRNA as it moves towards the clinic.