Spectroscopic and morphological studies on interaction between gold nanoparticle and liposome constructed with phosphatidylcholine. Issue 1 (10th March 2015)

• Record Type: Journal Article
• Authors: Tsukada, C; Tsuji, T; Matsuo, K; Nomoto, T; Kutluk, G; Sawada, M; Ogawa, S; Yoshida, T; Yagi, S
• Is Part Of: IOP conference series. Volume 76:Issue 1(2015)
• Page Start: 012001
• Publication Date: 2015-03-10
• Subjects: Materials science -- Periodicals; 620.1105
• DOI: 10.1088/1757-899X/76/1/012001
• Languages: English
• ISSNs: 1757-8981

Abstract

Abstract: The gold nanoparticles (Au NPs) colloidal solution and the phosphatidylcholine (PC) liposome aqueous solution are fabricated by the solution plasma method and the extrusion procedure, respectively. When the Au NPs colloidal solution and the PC liposome aqueous solution are mixed, considering the TEM image, we think that the Au NPs firstly are covered with the PC molecules, which do not contribute to form the PC liposome, and subsequently the Au NPs covered with the PC adsorb on the PC liposome surface. We propose that the PC molecule adsorbs on the Au sheet surface at the methyl group of N-CH3 and the oxygen atoms of P-O, P=O, C-O and C=O bonds, because each peak intensity of N, O and P K-edges NEXAFS spectra for the PC/Au sheet is reduced in comparison with that for the PC multilayer. Furthermore, the Au NPs covered with PC seem to be aggregated each other through the hydrophobic groups of PC on Au NPs.