Urinary biomarkers of podocyte injury. (December 2008)

• Record Type: Journal Article
• Authors: Camici, Marcello
• Is Part Of: Biomarkers in medicine. Volume 2:Number 6(2008)
• Page Start: 613
• Page End: 616
• Publication Date: 2008-12
• Subjects: biomarker -- podocyte -- urinary podocytes -- urinary podocyte-specific molecules; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/17520363.2.6.613
• Languages: English
• ISSNs: 1752-0363

Abstract

Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary podocyte-specific molecules (including PCR, immunoblotting and ELISA). Technical problems mean that it is still impossible to define a biomarker for urinary podocyte injury. This article also discusses the future perspectives for podocyturia studies, including fluorescence-activated cell sorting and the study of the proteome of urinary exosomes.