Role for glycocalyx perturbation in atherosclerosis development and associated microvascular dysfunction. (October 2007)

• Record Type: Journal Article
• Authors: Brands, Judith; Van Teeffelen, Jurgen WGE; Van den Berg, Bernard M; Vink, Hans
• Is Part Of: Future lipidology. Volume 2:Number 5(2007)
• Page Start: 527
• Page End: 534
• Publication Date: 2007-10
• Subjects: atherosclerosis -- blood flow regulation -- capillaries -- endothelial dysfunction -- flow-dependent dilation -- glycocalyx; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/17460875.2.5.527
• Languages: English
• ISSNs: 1746-0875

Abstract

The importance of the endothelial glycocalyx for vascular homeostasis is becoming more and more evident. This review addresses the potential relation between a damaged glycocalyx and the process of atherosclerosis, including the associated impairment in blood-flow regulation. We envision restoration of glycocalyx perturbation in the future as a potential therapy for early treatment of cardiovascular disease.